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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PLCG1 All Species: 18.18
Human Site: T386 Identified Species: 36.36
UniProt: P19174 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P19174 NP_002651.2 1290 148532 T386 Y H G H T L T T K I K F S D V
Chimpanzee Pan troglodytes XP_514650 1630 185027 T726 Y H G H T L T T K I K F S D V
Rhesus Macaque Macaca mulatta XP_001087295 1291 148567 T386 Y H G H T L T T K I K F S D V
Dog Lupus familis XP_542998 1249 143812 P368 A F V A S E Y P V I L S I E D
Cat Felis silvestris
Mouse Mus musculus Q62077 1302 149650 T386 Y H G H T L T T K I K F S D V
Rat Rattus norvegicus P10686 1290 148530 T386 Y H G H T L T T K I K F S D V
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus Q2VRL0 637 72514
Frog Xenopus laevis Q32NH8 758 87399
Zebra Danio Brachydanio rerio A5D6R3 784 89362
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P13217 1095 124845 R273 Y P L Y E E K R C T E I I N D
Honey Bee Apis mellifera XP_624101 1134 132613 D312 T T K I K F L D V I K T I K E
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_784329 940 107748 V118 N G N E T F T V P T E D S L D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79 99.5 93.2 N.A. 95.3 96.9 N.A. N.A. 21.4 21.7 21.8 N.A. 21.4 45.1 N.A. 35.1
Protein Similarity: 100 79 99.7 94.5 N.A. 96.7 98.2 N.A. N.A. 32.4 37.3 36.3 N.A. 40 62 N.A. 50
P-Site Identity: 100 100 100 6.6 N.A. 100 100 N.A. N.A. 0 0 0 N.A. 6.6 13.3 N.A. 20
P-Site Similarity: 100 100 100 20 N.A. 100 100 N.A. N.A. 0 0 0 N.A. 26.6 13.3 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 9 0 0 0 0 0 0 0 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 9 0 0 0 9 0 42 25 % D
% Glu: 0 0 0 9 9 17 0 0 0 0 17 0 0 9 9 % E
% Phe: 0 9 0 0 0 17 0 0 0 0 0 42 0 0 0 % F
% Gly: 0 9 42 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 42 0 42 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 9 0 0 0 0 0 59 0 9 25 0 0 % I
% Lys: 0 0 9 0 9 0 9 0 42 0 50 0 0 9 0 % K
% Leu: 0 0 9 0 0 42 9 0 0 0 9 0 0 9 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 9 0 9 0 0 0 0 0 0 0 0 0 0 9 0 % N
% Pro: 0 9 0 0 0 0 0 9 9 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 9 0 0 0 0 0 0 9 50 0 0 % S
% Thr: 9 9 0 0 50 0 50 42 0 17 0 9 0 0 0 % T
% Val: 0 0 9 0 0 0 0 9 17 0 0 0 0 0 42 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 50 0 0 9 0 0 9 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _